Automatisierte Kontextmodellierung bei kollektiver Informationsarbeit

Ziel der Arbeit ist die Entwicklung und Prüfung eines semantischen Informationssystems zur Unterstützung des Informations- und Wissenstransfers bei kollektiver, internetbasierter Informationsarbeit – sowohl innerhalb des Teams, als auch in dessen Übertragung in das Unternehmen. Als Informationssystem wird dabei ein System verstanden, welches die menschlichen Aufgabenträger, die organisationale und technische Ausgestaltung, aber auch die zu unterstützende Aufgabe determiniert und beinhaltet und von der Systemumwelt abgrenzt. Der Fokus der Arbeit ist in den Gegenstandsbereich der Wirtschaftsinformatik einzuordnen. Die Wirtschaftsinformatik besitzt nach dem Verständnis des Autors einen transdisziplinären Charakter und der Nukleus der Fachdisziplin ist als Intermediär verschiedener beteiligter, angrenzender Disziplinen zu verstehen. So sind bei der Betrachtung der avisierten Arbeit ebenso Einflüsse der Betriebswirtschaftslehre, der Informations- und Kommunikationstechno- logie, soziologischer sowie psychologischer Aspekte und nicht zuletzt linguistischer Grundlagen von Interesse für das Resultat bzw. Einflussdimensionen des Ergebnisses.:GRUNDLEGUNG I Problemkontext II Motivation zu dieser Arbeit III Ziel der Arbeit IV Forschungsdesign V Gang der Arbeit TEIL A: VERSTEHEN, LERNEN, WISSEN 1 Wissen und dessen Konstitution 1.1 Gegenstand des Wissens 1.2 Organisationale Epistemologie von Wissen 1.3 Einige Daten und Informationen zum Wissen 1.4 Die Natur des Wissens 1.5 Systematisierung der Arten von Wissen 1.6 Implikationen für diese Arbeit 2 Kommunikation & Verstehen 2.1 Partnerorientiertes Handeln 2.2 Kommunikation, Sprache und Textproduktion 2.3 Wahrnehmen, Verstehen & Rezipieren 2.4 Symbolische Interaktion 2.5 Barrieren der symbolischen Interaktion 2.6 Konsolidierung 3 Wissen & Lernen 3.1 Lernen in Schleifen 3.2 Theorien des individuelles Lernen 3.3 Kollektives Lernen 3.4 Die lernende Organisation 3.5 Kontinuum des Lernens 4 Wissenstransfer und die lernende Organisation 4.1 Strategien des Wissensmanagements 4.2 Wissens(re-)konstruktion 4.3 Erfolgsfaktoren für Wissenstransfer 4.4 Zyklische Wissensentstehung 4.5 Organisationale Wissensschaffung TEIL B: KOLLEKTIVE INFORMATIONSARBEIT & ORGANISATIONALES LERNEN 5 Informationsarbeit & Wissensschaffung 5.1 Vom Suchen und Finden von Informationen 5.2 Information Literacy & Recherchekompetenz 5.3 Informationsarbeit 5.4 Recherchestrategien 5.5 Phasen der internetbasierten Recherche 6 Organisation kollektiver Informationsarbeit 6.1 Intensität von Zusammenarbeit 6.2 Formale & informelle Arbeitsgruppen 6.3 Informationsarbeit im Team 6.4 Die Aufgabe als konstituierendes Merkmal 6.5 Individuelle Dispositionen 6.6 Gruppendynamik im Projektteam 6.7 Externe Unterstützung des Teams 6.8 Soziotechnischer Rahmen 6.9 Kollektive, internetbasierte Informationsarbeit 7 Die suchende Hypertextorganisation 7.1 Die organisationale Wissensbasis 7.2 Soziales Kapital & soziale Netzwerke 7.3 Wissen aus kollektiver Informationsarbeit 7.4 Kollektive Informationsarbeit und die lernende Organisation 7.5 Die lernende Organisation als Community of Communitys TEIL C: AUTOMATISIERTE KONTEXTMODELLIERUNG KOLLEKTIVER INFORMATIONSARBEIT 8 Konzeptuelle & technische Prämissen 8.1 Kernfunktionen der kollektiven Rechercheumgebung 8.2 Multidimensionalität vs. Multiperspektivität 8.3 Das Kontinuum semantischer Strukturmodelle 8.4 Konzepte der technischen Realisierung 9 Kontextschaffung bei kollektiver Informationsarbeit 9.1 Rechercheprozess und formale Objekte 9.2 Kollektive Terminologiearbeit und formale Rechercheobjekte 9.3 Kollektive Schaffung informationeller Mehrwerte 9.4 Explikation von Wissensträgern 10 Konzeption des soziotechnischen Informationssystems 10.1 Aufbau und Grundlegung des Systems 10.2 Grammatisches Metamodell – das Template der Templates 10.3 Templates der Nutzerkontexte und Gültigkeiten 10.4 Konzeptuelle Templates des Rechercheprozesses 10.5 Konzeptuelle Templates der kollektiven Informationsarbeit 10.6 Das Object Repository und die realen Objekte 10.7 Anwendung, Vernetzung & Synopsis des Systems 11 Wissensrepräsentation und kontextbasierte Wiederverwendung 11.1 Grundlagen der Wissensrepräsentation 11.2 Barrieren der Kognition expliziter Wissensrepräsentationen 11.3 Repräsentationsformen bei kollektiver Informationsarbeit 11.4 Dissemination & Zusammenarbeit: Nutzung der Rechercheumgebung 11.5 Six Pieces kollektiver Informationsarbeit für die lernende Organisation SYNOPSIS 12 Erkenntnisse der Arbeit und kritische Würdigung 12.1 Grundlegende Erkenntnisse der theoriegeleiteten Exploration 12.2 Hypothesenbildung: Synopsis der Erfahrungen 12.3 Hypothesenprüfung: Machbarkeit des System

Geteiltes Wissen und Retrieval: Ein Prozessmodell zur Unterstützung kollaborativer Suchprozesse

Hoher Wettbewerbsdruck wird für Unternehmen auf allen Ebenen immer stärker spürbar. Noch vor einigen Jahren gab es ganze Bereiche in Wirtschaft, Handel und öffentlicher Verwaltung, die bestenfalls auf eine technisch-inhaltliche Optimierung der jeweiligen Produkte und Leistungen orientiert waren. Dies hat weitgehend einer markt- und wettbewerbsorientierten Ausrichtung Platz gemacht, Innensicht wird durch verstärkte Außensicht ergänzt

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value &lt; 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p &lt; 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO